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Gender-Affirming Hormone Therapy
4.4 Rating
Oral (daily) or injection (variable)

Anti-Androgen Therapy

Medications that block or reduce the effects of androgens, commonly used alongside estrogen in feminizing hormone therapy.

Overview

Anti-androgens are medications that reduce the production or block the effects of testosterone and other androgens. Common options include spironolactone, bicalutamide, and GnRH agonists. They are typically used in conjunction with estradiol to enhance feminizing effects and suppress masculine features.

How It Works

Anti-androgens work through various mechanisms: spironolactone blocks androgen receptors and mildly inhibits testosterone production; bicalutamide competitively blocks the androgen receptor; GnRH agonists suppress gonadotropin release, reducing testosterone production at the source.

Benefits

Reduced body and facial hair
Enhanced feminizing effects
Decreased scalp hair loss
Reduced oil production
Support for breast development
Lower androgen levels

Potential Side Effects

Frequent urination (spironolactone)
Dizziness
Electrolyte changes
Fatigue
Breast tenderness
Mood changes

Dosage Information

Spironolactone: 100-200mg daily. Bicalutamide: 50mg daily. GnRH agonists: variable dosing per specific medication. Always prescribed and monitored by a qualified provider.

Quick Facts

Administration

Oral (daily) or injection (variable)

Rating

4.4 / 5.0

Category

Gender-Affirming Hormone Therapy

Common Symptoms

Persistent masculinization
Incomplete feminization
Unwanted body hair
High androgen levels
Related Treatments
Feminizing Estrogen TherapyMasculinizing Testosterone Therapy

Common Questions

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